Comparison of Different Nanosuspensions as Potential Ophthalmic Delivery Systems for Ketotifen Fumarate
نویسندگان
چکیده
منابع مشابه
Design of eudragit RL nanoparticles by nanoemulsion method as carriers for ophthalmic drug delivery of ketotifen fumarate
Objective(s): Ketotifen fumarate (KF) is a selective and noncompetitive histamine antagonist (H1-receptor) that is used topically in the treatment of allergic conditions of rhinitis and conjunctivitis. The aim of this study was to formulate and improve an ophthalmic delivery system of KF.Ocular nanoparticles were prepared with the objective of reducing the frequency of administration and obtain...
متن کاملdesign of eudragit rl nanoparticles by nanoemulsion method as carriers for ophthalmic drug delivery of ketotifen fumarate
objective(s): ketotifen fumarate (kf) is a selective and noncompetitive histamine antagonist (h1-receptor) that is used topically in the treatment of allergic conditions of rhinitis and conjunctivitis. the aim of this study was to formulate and improve an ophthalmic delivery system of kf.ocular nanoparticles were prepared with the objective of reducing the frequency of administration and obtain...
متن کاملDesign of eudragit RL nanoparticles by nanoemulsion method as carriers for ophthalmic drug delivery of ketotifen fumarate
OBJECTIVES Ketotifen fumarate (KF) is a selective and noncompetitive histamine antagonist (H1-receptor) that is used topically in the treatment of allergic conditions of rhinitis and conjunctivitis. The aim of this study was to formulate and improve an ophthalmic delivery system of KF. Ocular nanoparticles were prepared with the objective of reducing the frequency of administration and obtainin...
متن کاملBiodegradable fumarate-based drug-delivery systems for ophthalmic applications.
The function of a photocrosslinked poly(propylene fumarate) (PPF)/poly(N-vinyl pyrrolidone) (PVP) matrix for the sustained release of three ophthalmic model drugs, acetazolamide (AZ), dichlorphenamide (DP), and timolol maleate (TM), was investigated. The drugs differ in molecular weight and degree of dissociation in aqueous environments; both are parameters that significantly influence drug dif...
متن کاملFabrication and in vitro evaluation of Ketotifen Fumarate-loaded PLGA nanoparticles as a sustained delivery system
Abstract Ketotifen fumarate is a non-bronchodilator anti-asthmatic drug which inhibits the effects of certain endogenous substances known to be inflammatory mediators, and thereby exerts antiallergic activity. The present study describes the formulation of a sustained release nanoparticle (NP) drug delivery system containing ketotifen, using poly (D,L lactide-co-glycolide acid) (PLGA). Biodegra...
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ژورنال
عنوان ژورنال: Advanced Pharmaceutical Bulletin
سال: 2016
ISSN: 2228-5881,2251-7308
DOI: 10.15171/apb.2016.046